The need for a major effort to produce nasal vaccine.
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During the first year of the pandemic, meaningful evolution of the virus was slow-paced, without any functional consequences, but since that time we have seen a succession of important variants of concern, with increasing transmissibility and immune evasion, culminating in the Omicron lineages. With that, there has been a dramatic falloff in the capacity for vaccinations and booster shots to block infections and transmission (2). A major unmet clinical need has arisen to block the transmission chain, prevent the frequent breakthrough infections, and achieve high levels of durable protection against severe disease, no less prevent post-acute sequelae of SARS-CoV-2 infection (PASC, Long COVID-19).
That has spotlighted the possibility of nasal vaccines, with their allure for achieving mucosal immunity, complementing, and likely bolstering the circulating immunity achieved via intramuscular shots. A new report by Tang and colleagues (3) sheds considerable light on the shortcomings of mRNA vaccines for not achieving respiratory mucosal immunity against Omicron in people, while also showing how well this can be accomplished with a nasal vaccine in mice.
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Given the current political climate it seems unlikely to happen.
trump's new swamp
If he gets a second term..
13:48 in Current Affairs, General Commentary | Permalink | Comments (0)