Turing appears to have been on the right track
snip
...
The question of how cat stripes and splotches are made touches on some of the deepest theoretical puzzles of biology. How does a blob of cells organize itself into a fruit fly, or a panda? What tells the bones in a limb to become a hand, or paw, or the ribbing of a leathery wing? What tells some skin cells to grow dark hair and others lighter hair?
A team of geneticists reported Tuesday in the journal Nature Communications that it had identified a gene in domestic cats that plays a key role in creating the traditional tabby stripe pattern, and that the pattern is evident in embryonic tissue even before hair follicles start to grow.
The inheritance of cat coats — how to breed for this or that pattern — is well known. But how patterns emerge in a growing embryo “really has been an unsolved mystery,” said Dr. Gregory S. Barsh, an author of the new report.
...
Here's the paper. Turing considered his reaction-diffusion patterning mechanism to be his most important work.
Developmental genetics of color pattern establishment in cats
Christopher B. Kaelin, Kelly A. McGowan & Gregory S. Barsh
Nature Communications volume 12, Article number: 5127 (2021)
Abstract
Intricate color patterns are a defining aspect of morphological diversity in the Felidae. We applied morphological and single-cell gene expression analysis to fetal skin of domestic cats to identify when, where, and how, during fetal development, felid color patterns are established. Early in development, we identify stripe-like alterations in epidermal thickness preceded by a gene expression pre-pattern. The secreted Wnt inhibitor encoded by Dickkopf 4 plays a central role in this process, and is mutated in cats with the Ticked pattern type. Our results bring molecular understanding to how the leopard got its spots, suggest that similar mechanisms underlie periodic color pattern and periodic hair follicle spacing, and identify targets for diverse pattern variation in other mammals.
ann telnaes 20 years ago
Ann Telnaes of The Washington Post looks back 20 years.
09:31 in Art, General Commentary, history | Permalink | Comments (0)