leaps of faith

minipost

Yesterday I had my first jab of a Covid-19 vaccine - specifically the Pfizer mRNA vaccine.  Despite political, production, and distribution issues several vaccines appeared and more are coming.  Going from decoding the SARS-CoV-2 genome to first injections took only about a half year and a year later a few hundred million doses have been produced. While some corners were safely cut, the real story - at least for the new mRNA vaccines - began nearly thirty years earlier.  

 

Katalin Karikó's work will certainly win her a Nobel Prize next year.   Here's a good telling of the story.  A major point is the work was judged unworthy and finding support was nearly impossible.  After about ten years another player, Drew Weissman, entered and the two of them managed to crack the final bits of the problem.  He'll certainly be sprinkled with the Swedish holy water too. The mRNA approach is important well beyond the current pandemic - it may mark a fundamental change in medicine.  It wouldn't have happened - at least not as soon as it did - without a certain type of reserch.  

 

Curiosity-driven fundamental research requires a certain type of scientist, time and resources.  While much of it fails to produce an immediately useful result,  it has an established track record of changing the world.  Industries don't do this kind of work anymore.  Most universities shy from it - there's a tendency to want results-focused work.  When it's funded you usually find it in physics and astronomy  rather than the biological sciences and that's a problem.   These leaps are driven by hope and curiosity.  They open doors that often require more than a decade of work - usually by other people in different organizations.   Expanding this work is how you create radical change.  I'd never argue results-driven research should be cut - after all, that's where the next five to twenty years come from.  But I'd love to see the Katalin Karikós of the world given more of a space.  And then there are the spin-offs - a good deal of the instrumentation used in medicine came out of  fundamental physics - but that's another set of stories.

 

Comments

[Brian Phipps]

Steve,

Great story, and a very useful link. Thanks!

Brian

(Hopefully getting my second Moderna shot in a few days.)

[Charles Hess]

Steve, a message that needs to be sung from mountaintops ( commented on by a non-scientist who appreciates the power of “ leaps of faith”) thanks!!!
Charlie