Every day, millions of people are taking medications that will not help them. The top ten highest-grossing drugs in the United States help between 1 in 25 and 1 in 4 of the people who take them (see 'Imprecision medicine'). For some drugs, such as statins — routinely used to lower cholesterol — as few as 1 in 50 may benefit1. There are even drugs that are harmful to certain ethnic groups because of the bias towards white Western participants in classical clinical trials2.
Recognition that physicians need to take individual variability into account is driving huge interest in 'precision' medicine. In January, US President Barack Obama announced a US$215-million national Precision Medicine Initiative. This includes, among other things, the establishment of a national database of the genetic and other data of one million people in the United States.
“Yi might have moved through the air with a combination of flapping and gliding flight, though it probably relied more on gliding,” says Xu, who is planning to search for more specimens. “There are many questions remaining to answer about this bizarre dinosaur.”
For now, this discovery reminds us that the evolution of flight among birds and other dinosaurs was not a simple story. In the late Jurassic period, when Yi lived, there were all manner of dinosaurs with varying shapes, sizes, and numbers of wings. It was a world of not-quite-birds and just-about-birds—and now bat-winged dinosaurs, too! “What a grand age of experimentation!“ says Ksepka.
Small nuclear reactors come in several flavors. Many universities have research reactors that aren't intended to produce power, but some somewhat larger reactors have been built to supply power for ships, submarines, remote facilities and commercial power. There are those who suggest newer versions are solutions to cheap and clean power. Looking at the past suggests one has proceed with some caution.
A talk from the late 90s at the Computer History Museum on the SAGE system The Semi-Automatic Ground Environment - one of the major computer developments in the late 50s and early 60s. Radar based early warning with automatic guidance of fighter interceptors with networked computer control. Billions of $...
some of the speakers are more interesting than others
In all candidness, I shouldn’t have been in Solomeo. I don’t write for a big fashion magazine. I have no credibility in Brunello Cucinelli's world. But after a friend heard me wax eloquent about well-made cashmere sweaters for nearly an hour, he suggested that I should perhaps meet this guy in Italy. An email introduction led to an open invitation to come visit his hamlet whenever I was in Italy. Last April, I found myself in Perugia for the Journalism Festival and chanced on a visit. Brunello’s response? Come right over. The self-made billionaire greeted me at the door as if I was his long-lost friend. I felt as if I had known him all of my life, just hadn’t met him. I had bought two of his sweaters almost seven years ago, when I had lost a lot of weight (which I have since regained), but his clothes aren't really part of my wardrobe. And yet I have admired them, as well as his stores and his ethics. For example, he gives 20 percent of his company's profits to his charitable foundation in the name of “human dignity” and pays his workers wages that are 20 percent higher than the industry standard, mostly because it allows his company to encourage and continue the Italian craftsman traditions. Cucinelli also pays for an artisan’s school in Solemeo: Young people are free to work either at his company or for another Italian company. The on-campus cafe is way more beautiful than Google Cafe or Facebook’s facilities. And the pasta is really heavenly. The company, which trades on the Milan Stock Exchange, is doing well: about 356 million euros in revenues in 2014. Brunello is part businessman, part philosopher and part monk. He is not Jeff Bezos or Larry Page. He certainly isn’t chief executive of an oil company. He is the anti-LVMH, and that is what makes him interesting. We were supposed to meet for 30 minutes but ended up spending a few hours talking about everything from Marcus Aurelius to Barack Obama to Steve Jobs to his father, a farmer. Here is a snapshot of our rambling two-hour conversation, facilitated by an Italian translator. There are so many lessons here for founders, especially the importance of giving back.