The current issue of Naturereports that exercise also promotes cellular autophagy in rats. A long jump to humans, but the lead researcher said this was enough information enough to get her to get into a regular exercise routine. If it pans out it might explain several benefits of exercise.
Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis
Received 22 September 2010 Accepted 06 December 2011 published online 18 January 2012
Exercise has beneficial effects on human health, including protection against metabolic disorders such as diabetes1. However, the cellular mechanisms underlying these effects are incompletely understood. The lysosomal degradation pathway, autophagy, is an intracellular recycling system that functions during basal conditions in organelle and protein quality control2. During stress, increased levels of autophagy permit cells to adapt to changing nutritional and energy demands through protein catabolism3. Moreover, in animal models, autophagy protects against diseases such as cancer, neurodegenerative disorders, infections, inflammatory diseases, ageing and insulin resistance4, 5, 6. Here we show that acute exercise induces autophagy in skeletal and cardiac muscle of fed mice. To investigate the role of exercise-mediated autophagy in vivo, we generated mutant mice that show normal levels of basal autophagy but are deficient in stimulus (exercise- or starvation)-induced autophagy. These mice (termed BCL2 AAA mice) contain knock-in mutations in BCL2 phosphorylation sites (Thr69Ala, Ser70Ala and Ser84Ala) that prevent stimulus-induced disruption of the BCL2–beclin-1 complex and autophagy activation. BCL2 AAA mice show decreased endurance and altered glucose metabolism during acute exercise, as well as impaired chronic exercise-mediated protection against high-fat-diet-induced glucose intolerance. Thus, exercise induces autophagy, BCL2 is a crucial regulator of exercise- (and starvation)-induced autophagy in vivo, and autophagy induction may contribute to the beneficial metabolic effects of exercise.
TO date, no study has found any long-term benefit of attention-deficit medication on academic performance, peer relationships or behavior problems, the very things we would most want to improve. Until recently, most studies of these drugs had not been properly randomized, and some of them had other methodological flaws.
But in 2009, findings were published from a well-controlled study that had been going on for more than a decade, and the results were very clear. The study randomly assigned almost 600 children with attention problems to four treatment conditions. Some received medication alone, some cognitive-behavior therapy alone, some medication plus therapy, and some were in a community-care control group that received no systematic treatment. At first this study suggested that medication, or medication plus therapy, produced the best results. However, after three years, these effects had faded, and by eight years there was no evidence that medication produced any academic or behavioral benefits.
I've seen many auroral displays and one of my issues with those shown on the web is they are not real time. This is usually a requirement as image quality is often low at high sensitivity settings on the camera. Also many like showing the drama speeded up dramatically.
here is one in real time - shot at iso 6400 ... much closer to what you see in the wild!
Yes, people manage diabetes, and some really disciplined people wean themselves off medication with a regimen of diet and exercise, but that's a long, long way from what most of us consider "moderation," which usually involves saying no to a second slice of cake. Besides, a diabetic never gets a day off.
The life of a diabetic is somewhat less than swell — but Novo Nordisk is selling swell, alongside drug companies that promise to medicate away depression, gas, incontinence, clogged arteries and fibromyalgia. According to the Congressional Budget Office, pharmaceutical companies spent $4.7 billion on direct-to-consumer advertising in 2008; the United States has the dubious distinction of being one of only two countries in the world to allow such advertising, New Zealand being the other.
Support and encouragement is one thing, but what we're being sold is magical thinking. In the battle between healthcare reality and fantasy, Paula Deen is small potatoes (steamed, skins on, no butter), but what she represents matters: another attempt to market immortality to a culture that's particularly in love with misbehaving, followed by an easy fix.